Section of Pharmaceutical Design and Drug Delivery,
Department of Pharmacy
University of Copenhagen
Faculty of Health and Medical Sciences
Main Research Interests
My whole research career, both in academia and industry (see employment record) has always focussed on improving drug delivery systems. The exact topics of course have shifted over the years, and span from colloidal delivery systems (including liposomal and other liquid crystalline systems, polymeric and lipid nanoparticles for drug and vaccine delivery) to solids state dosage forms, including polymorphic drugs and amorphous drugs delivery systems. Always (and also in the past five years) the work has been strongly based on a physicochemical underpinning of these enabling formulations, as well as a deep and thorough analytical characterisation and understanding of such systems. Work in recent years has increasingly used thermal analytical, diffractometric, and spectroscopic methods, both quantitatively and structurally. At the same time another focus has always been on the preparative aspects of such enabling formulations, including technologies such as spray drying, melt extrusion, mechano-chemical activation, tabletting, encapsulation etc.
Since March 2012, Professor Thomas Rades is the Research Chair in Pharmaceutical Design and Drug Delivery in the Department of Pharmacy, University of Copenhagen. Before that he has been the Chair in Pharmaceutical Sciences at the National School of Pharmacy, University of Otago, New Zealand from 2003 – 2012.
In 1994 he received a PhD from the University of Braunschweig, Germany for his work on thermotropic and lyotropic liquid crystalline drugs. After working as a Research Scientist in the Preclinical Development and Formulation at F. Hoffmann-La Roche in Basel, Switzerland, he became a Senior Lecturer in Pharmaceutical Sciences at Otago in 1999 and since 2003 held the Chair in Pharmaceutical Sciences in Otago.
Professor Rades has developed an international reputation for his research in the physical characterization of drugs solid dosage forms as well as in vaccine delivery using nanoparticulate systems (both polymeric and lipid based). Prof Rades has published more than 400 papers in international peer review journals as well as several book chapters and patents and one book. Prof Rades is an Editor of the Journal of Pharmaceutical Sciences and the European Journal of Pharmaceutics and Biopharmaceutics and an Associate Editor of the Journal of Pharmacy and Pharmacology. He holds an honorary doctorate of Åbo Akademie University, Finland, a visiting professorship at the Department of Medicine at the University of Adelaide, Australia and an honorary professorship at the University of Otago, New Zealand. He is an Eminent Fellow of the Academy of Pharmaceutical Sciences (UK) and a Fellow of the New Zealand Institute of Chemistry. Professor Rades has successfully supervised more than 75 PhD students. For his undergraduate and postgraduate teaching he was awarded the New Zealand Tertiary Teaching Excellence Award for Sustained Excellence (2005).
His research interests include the solid state of drugs and dosage forms, and Nanoparticles as delivery systems for drugs and vaccines. Research in both areas aims to improve drug therapy through appropriate formulation and characterisation of medicines and to increase understanding of the physico-chemical properties of drugs and medicines. It combines physical, chemical, and biological sciences and technology to optimally formulate drugs and vaccines for human and veterinary uses.