Radiation-induced in situ amorphization

26 July 2021 in Research Highlights 64 hits

In situ amorphization is a recent approach in the preparation of amorphous solid dispersions (ASD). Compared to common preparation methods…

Extrusion-based 3D printing of oral solid dosage forms: Material requirements and equipment dependencies

16 March 2021 in Research Highlights 1240 hits

Fused-deposition modelling or extrusion-based 3D printing is a flexible manufacturing technique and can be used for dose personalisation. At the…

Continuous twin screw granulation: Impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API

20 January 2021 in Research Highlights 1485 hits

Despite the recent commercialization of several drug products manufactured through continuous manufacturing techniques, knowledge on the formulation aspect of these…

Investigating the complex phase behavior and drug release of ternary solid dispersions based on ethyl cellulose

18 December 2020 in Research Highlights 1903 hits

In this work, the insoluble hydrophobic polymer ethyl cellulose (EC) was investigated as a potential carrier for the formulation of…

Development of a surface coating technique with predictive value for bead coating in the manufacturing of amorphous solid dispersions

05 October 2020 in Research Highlights 2678 hits

The aim of this research was to investigate whether a surface coating technique could be developed that can predict the…

Stabilization of amorphous drugs; are crystalline inorganic excipients a way forward?

24 August 2020 in Research Highlights 3981 hits

Physical instability arguably is the major challenge in using neat amorphous active pharmaceutical ingredients in everyday tablets and capsules [1].…

Effect of particle size and deformation behaviour on water ingress into tablets

22 July 2020 in Research Highlights 3561 hits

Check out this commented presentation by Anne Linnet Skelbæk-Pedersen

Machine-Vision-Enabled Salt Dissolution Analysis

19 July 2020 in Research Highlights 3467 hits

Here's a commented presentation from Jerneij Stukelj from the University of Helsinki, Finland.


21 April 2020 in Research Highlights 4811 hits

Pharmaceutics (ISSN 1999-4923, click here) is an open access journal which provides an advanced forum for the science and technology…

Inaugural meeting of the research cluster

Cluster meeting photo.

Group photo of the first cluster meeting in San Antonio, TX November 2006. From left to right: Jyrki Heinämäki, Jouko Yliruusi, Jukka Rantanen, Jean Paul Remon, Thomas Rades, Clare Strachan, Axel Zeitler, Peter Kleinebudde.

Expansion of the cluster

In January 2008 the PSSRC expanded and the group of Prof. Juergen Siepmann at the University of Lille joined the cluster. 

In August 2008 the group of João Pinto from the University of Lisbon joined the PSSRC at the 2nd PSSRC symposium. 

In September 2011 the groups of Johannes Khienast from the Technical University of Graz (Austria), Guy Van den Mooter from the University of Leuven (Belgium) and Stane Srcic from the University of Ljubljana (Slovenia) joined the cluster at the 5th PSSRC symposium.

Annual Symposia

Since its foundation one PSSRC symposium has taken place each year:

2007 Düsseldorf
2008 Ghent
2009 Copenhagen
2010 Cambridge
2011 Helsinki
2012 Lisbon
2013 Lille
2014 Lublijana
2015 Ghent
2016 Copenhagen

A particular aim of the symposium is to provide the younger members of the cluster with an opportunity to present their work. The symposium started as a closed meeting for cluster members only. The closed meeting consists of oral presentations of 10 minutes duration followed by 10 minutes of discussion of each paper. All sessions are chaired by PhD students and postdocs and the presentations are exclusively given by junior cluster members.

Following the success of the early symposia, in recent years the format of the meeting was extended to include an open day as well where the more senior cluster members present their research to the wider pharmaceutical community across academia and industry.

View the embedded image gallery online at:


For enquiries and questions please email to This email address is being protected from spambots. You need JavaScript enabled to view it..

Research in the eight cluster centres is aiming to improve medicinal products by overcoming the current limitations on the molecular, particulate, process and product level through a better understanding of the fundamental science that is causing these limitations.

The research activities in the different cluster centres are focusing on improving process understanding through development of novel analytical solutions enabling efficient process monitoring and control solutions, and further, on modelling solutions in these environments.

The major research theme in the cluster is focusing on the understanding of the science behind common pharmaceutical processing operations from both an applied and a fundamental perspective. The development of different analytical techniques with a special emphasis on spectroscopic techniques is an essential prerequisite for increased process understanding.

The PSSRC cluster centers have available all critical unit operations of pharmaceutical relevance for joint projects and for industrial co-operation projects. PSSRC is the ideal partner for support in analytical process research and related intellectual property issues.

The following section of the website gives an overview of the different areas of research in the PSSRC.

Processing of pharmaceuticals

Spray drying 
Freeze drying 

High shear wet granulation
Fluid bed granulation
Roller compaction


Process Analytical Technologies (PAT)
Quality by Design (QbD)
Scale up
Continuous processing





Intramolecular level

Intermolecular level

Particulate level

Vibrational spectroscopy - mid and near infrared (NIR), Raman
Solid state NMR

X-ray diffraction (XRPD)
Optical and electron microscopy (PLM, SEM and TEM)
Thermal analytical techniques (DSC, TGA)
Vibrational spectroscopy(terahertz/ far infrared)

Micrometrics (surface area, density, porosity)
Powder characterisation (particle size, shape, distributions, flow properties)
Water sorption
Surface properties (AFM)

 Chemical Mapping

Dosage form level


Infrared, NIR and Raman


Solid-form screening

X-ray microtomography
Magnetic resonance imaging (MRI)
Terahertz pulsed imaging (TPI)
Optical coherence tomography (OCT)

Dissolution testing and modelling






Molecular properties

Particle ensemble level

Process conditions

Fundamental molecular properties
Chemometrics and data mining

Discrete element modelling
Computational fluid dynamics
Drug release mechanisms  

Mechanisms of solid state transformations