Thursday, 08 November 2018 13:03

Last PSSRC Meeting in Leuven in Belgium

The twelfth annual meeting of the Pharmaceutical Solid State Research Cluster was held in Leuven (University of Leuven, KU Leuven) from 12 to 14 September 2018. It was attended by 122 participants (91 during the closed days and 31 during the open day) from the member research groups and alumni across Europe.
A new method for measuring of molecular mobility in glassy materials has been developed using terahertz spectroscopy. The absorption level of amorphous drugs at terahertz frequencies below Tg correlates with the stability of the drug as an amorphous solid. The molecular mobility responsible for the glass crystallisation significantly decreases at around a universal value of 0.67 Tg. This explains why the commonly used rules of thumb for glasses to remain stable below 0.8 Tg or Tg – 20 K do not work reliably. These results reveal a unique and completely novel opportunity to predict and test the stability of amorphous…