Special Issue of DOSIS

Articles presented at the Helsinki Drug Research 2008 (HDR)

Documents

Co-crystals: an emerging approach for enhancing properties of pharmaceutical solids

Sabiruddin Mirza, Inna Miroshnyk, Jyrki Heinämäki, Jouko Yliruusi: Co-crystals: an emerging approach for enhancing properties of pharmaceutical solids p. 90

Computer-aided design and optimisation for pharmaceutical formulations

Kozo Takayama: Computer-aided design and optimisation for pharmaceutical formulations p. 114

Editorial

Diversity of dosage form research – molecular, nano, micro and macro perspective

This is the online repository of the articles published in DOSIS vol. 24 issue 2, 2008

Helsinki Drug Research 2008 (www.hdr.fi) is a scientific meeting designed to provide a complete educational event allowing each and every attendee, both from the academia and industry, the ability to customize their experience with the goal of advancing pharmaceutical research. HDR 2008 has six symposia covering selected areas of drug development and use.

The invited authors of this special issue have been chosen from the speakers of two symposia with the topics "Pharmaceutical Manufacturing Research" and "Nano and Microtechnology in Pharmacy". These two symposia have been planned to have the boundaries of traditional disciplines as vague as possible. Therefore, we have chosen articles that are multidisciplinary and increase cross-interaction. We believe that it will benefit the modern drug research. Thus, the topics of the articles in this journal focusing on solid dosage forms have a wide variety ranging from molecular level topics on drug crystal design, modelling of mixing during crystallisation and understanding of formation of optimal particle size distribution, utilisation of modern computer-aided design and data analysis in formulation development and reaching to the macroscale process technology such as hot melt extrusion. Nanocrystals and nanoparticles have been chosen as a special case of novel type of solid dosage forms having special challenges in their formulations and processing. In addition to the invited authors this issue has three articles of young scientists, who have recently finished their PhD thesis on the areas of solid state material research and nanoparticles.

Excerpt from the Editorial by Anne Juppo

 

EDITORIAL - PÄÄKIRJOITUS, Anne Juppo: Diversity of dosage form research - molecular, nano, micro and macro perspective p. 88

Effects of mixing in pharmaceutical product design

Jerzy Baldyga: Effects of mixing in pharmaceutical product design p. 97

Feasibility of silicon-based mesoporous materials for oral drug delivery applications

Jouni Hirvonen, Timo Laaksonen, Leena Peltonen, Hélder Santos; Vesa-Pekka Lehto, Teemu Heikkilä, Joakim Riikonen, Ermei Mäkilä, Jarno Salonen: Feasibility of silicon-based mesoporous materials for oral drug delivery applications p. 129

Hot-melt extrusion and injection moulding as manufacturing tools for controlled release formulations

Chris Vervaet, Ellen Verhoeven, Thomas Quinten, Jean Paul Remon: Hot-melt extrusion and injection moulding as manufacturing tools for controlled release formulations p. 119

Second generation of drug nanocrystals for delivery of poorly soluble drugs: smartCrystals technology

Cornelia Keck, Szymon Kobierski, Rachmat Mauludin, Rainer H. Müller: Second generation of drug nanocrystals for delivery of poorly soluble drugs: smartCrystals technology p. 124

Understanding solid-state transformations during dehydration: new insights using vibrational spectroscopy and multivariate modelling

Karin Kogermann: Understanding solid-state transformations during dehydration: new insights using vibrational spectroscopy and multivariate modelling. p. 150