×

Warning

JUser: :_load: Unable to load user with ID: 906
JUser: :_load: Unable to load user with ID: 811
JUser: :_load: Unable to load user with ID: 829
JUser: :_load: Unable to load user with ID: 1436
Thursday, 28 February 2013 14:25

Paradigm Shift in Lipid-Based Drug Delivery?

Written by

Lipid-based drug delivery systems have become a popular approach for the delivery of poorly water-soluble drugs. The limitations associated with this formulation strategy have been the drug solubility in the delivery systems and the lack of characterization techniques predicting the in vivo performance. Solid state characterization of the in vitro digestion products has provided new insights that scrutinize current paradigms in the development of lipid-based drug delivery systems.

Monday, 25 February 2013 18:19

Co-Amorphous Drug Delivery Systems

Written by

Formulation of co-amorphous drug systems

Using the amorphous form of a drug, instead of its crystalline counterpart is one way to enhance the bioavailability of poorly water-soluble drugs. However, in order to fully benefit from the solubility advantages of amorphous drugs, one needs to overcome phyisco-chemical limitations including poor physical stability associated with the amorphous form. Co-amorphous drug formulations are a novel and one of the most promising formulation approaches in this context, where the drug in its amorphous form is stabilized through strong intermolecular interactions with its co-amorphous low molecular weight partner molecule.

Tuesday, 05 February 2013 16:35

Rapid approaches for exploring solid form landscape

Written by

The major challenge during preformulation is to gain the greatest possible knowledge about candidate drug compounds with minimal use of resources. Therefore, rapid approaches are proposed for identifying critical conditions for existence of various solid forms so that sudden appearance of new forms and unpredictable stability issues can be avoided during later stages of product development.

Tuesday, 29 January 2013 00:00

Microstructure of Film Coated Tablets

Written by

Terahertz Pulsed Imaging

Since 2007 when terahertz pulsed imaging (TPI) was first developed to non-destructively measure the coating thickness of pharmaceutical tablets there has been intense research in the PSSRC into how this technique can help improve the quality of pharmaceutical coatings and thus make controlled release technology based on coatings of single dosage forms attractive to industry.

Page 3 of 3