Control performance of different roll compactors

22 December 2016 in Research Highlights 7531 hits

Written by Kitti Csordas, early stage researcher in the IPROCOM project

Does PLGA microparticle swelling control drug release?

26 January 2016 in Research Highlights 13039 hits

Background Poly(lactic-co-glycolic acid) (PLGA)-based microparticles offer a great potential as parenteral controlled drug delivery systems [1]. Different types of drug…

Ensuring thermodynamic stability of amorphous solid dispersions by predicting drug-polymer solubility

25 November 2015 in Research Highlights 18859 hits

The potential of amorphous solid dispersions to improve the solubility, dissolution rate and bioavailability of poorly water soluble drugs is…

Downstream processing of a co-amorphous drug-amino acid formulation

18 November 2015 in Research Highlights 13625 hits

For the first time, an appropriate solid dosage form was developed for a co-amorphous drug-amino acid formulation, demonstrating the high…

Beyond Traditional Disintegration Testing

17 June 2015 in Research Highlights 20444 hits

We have developed a new technique to better understand what happens to the microstructure inside a tablet during rapid disintegration.

Improved Process Understanding of Tablet Film Coating

08 October 2014 in Research Highlights 29486 hits

Background Terahertz pulsed imaging (TPI) was first introduced in 2007 to non-destructively measure the coating thickness of pharmaceutical tablets. Ever…

Effect of Compression on Local and Segmental Mobility of PVPVA: Broadband Dielectric Spectroscopy Study

11 September 2014 in Research Highlights 25529 hits

Background The mechanism of plastic deformation in amorphous polymers is still obscure due to lack of experimental techniques to probe…

Nanocrystals - from fast dissolution and improved solubility to controlled release applications

02 July 2014 in Research Highlights 24248 hits

Problems related to low oral bioavailability due to poor solubility of new drug candidates are an increasing challenge in pharmaceutical…

Inaugural meeting of the research cluster

Cluster meeting photo.

Group photo of the first cluster meeting in San Antonio, TX November 2006. From left to right: Jyrki Heinämäki, Jouko Yliruusi, Jukka Rantanen, Jean Paul Remon, Thomas Rades, Clare Strachan, Axel Zeitler, Peter Kleinebudde.

Expansion of the cluster

In January 2008 the PSSRC expanded and the group of Prof. Juergen Siepmann at the University of Lille joined the cluster. 

In August 2008 the group of João Pinto from the University of Lisbon joined the PSSRC at the 2nd PSSRC symposium. 

In September 2011 the groups of Johannes Khienast from the Technical University of Graz (Austria), Guy Van den Mooter from the University of Leuven (Belgium) and Stane Srcic from the University of Ljubljana (Slovenia) joined the cluster at the 5th PSSRC symposium.

Annual Symposia

Since its foundation one PSSRC symposium has taken place each year:

2007 Düsseldorf
2008 Ghent
2009 Copenhagen
2010 Cambridge
2011 Helsinki
2012 Lisbon
2013 Lille
2014 Lublijana
2015 Ghent
2016 Copenhagen

A particular aim of the symposium is to provide the younger members of the cluster with an opportunity to present their work. The symposium started as a closed meeting for cluster members only. The closed meeting consists of oral presentations of 10 minutes duration followed by 10 minutes of discussion of each paper. All sessions are chaired by PhD students and postdocs and the presentations are exclusively given by junior cluster members.

Following the success of the early symposia, in recent years the format of the meeting was extended to include an open day as well where the more senior cluster members present their research to the wider pharmaceutical community across academia and industry.

View the embedded image gallery online at:


For enquiries and questions please email to This email address is being protected from spambots. You need JavaScript enabled to view it..

Research in the eight cluster centres is aiming to improve medicinal products by overcoming the current limitations on the molecular, particulate, process and product level through a better understanding of the fundamental science that is causing these limitations.

The research activities in the different cluster centres are focusing on improving process understanding through development of novel analytical solutions enabling efficient process monitoring and control solutions, and further, on modelling solutions in these environments.

The major research theme in the cluster is focusing on the understanding of the science behind common pharmaceutical processing operations from both an applied and a fundamental perspective. The development of different analytical techniques with a special emphasis on spectroscopic techniques is an essential prerequisite for increased process understanding.

The PSSRC cluster centers have available all critical unit operations of pharmaceutical relevance for joint projects and for industrial co-operation projects. PSSRC is the ideal partner for support in analytical process research and related intellectual property issues.

The following section of the website gives an overview of the different areas of research in the PSSRC.

Processing of pharmaceuticals

Spray drying 
Freeze drying 

High shear wet granulation
Fluid bed granulation
Roller compaction


Process Analytical Technologies (PAT)
Quality by Design (QbD)
Scale up
Continuous processing





Intramolecular level

Intermolecular level

Particulate level

Vibrational spectroscopy - mid and near infrared (NIR), Raman
Solid state NMR

X-ray diffraction (XRPD)
Optical and electron microscopy (PLM, SEM and TEM)
Thermal analytical techniques (DSC, TGA)
Vibrational spectroscopy(terahertz/ far infrared)

Micrometrics (surface area, density, porosity)
Powder characterisation (particle size, shape, distributions, flow properties)
Water sorption
Surface properties (AFM)

 Chemical Mapping

Dosage form level


Infrared, NIR and Raman


Solid-form screening

X-ray microtomography
Magnetic resonance imaging (MRI)
Terahertz pulsed imaging (TPI)
Optical coherence tomography (OCT)

Dissolution testing and modelling






Molecular properties

Particle ensemble level

Process conditions

Fundamental molecular properties
Chemometrics and data mining

Discrete element modelling
Computational fluid dynamics
Drug release mechanisms  

Mechanisms of solid state transformations