Does PLGA microparticle swelling control drug release?

26 January 2016 in Research Highlights 3313 hits

Background Poly(lactic-co-glycolic acid) (PLGA)-based microparticles offer a great potential as parenteral controlled drug delivery systems [1]. Different types of drug…

Ensuring thermodynamic stability of amorphous solid dispersions by predicting drug-polymer solubility

25 November 2015 in Research Highlights 6872 hits

The potential of amorphous solid dispersions to improve the solubility, dissolution rate and bioavailability of poorly water soluble drugs is…

Downstream processing of a co-amorphous drug-amino acid formulation

18 November 2015 in Research Highlights 4749 hits

For the first time, an appropriate solid dosage form was developed for a co-amorphous drug-amino acid formulation, demonstrating the high…

Beyond Traditional Disintegration Testing

17 June 2015 in Research Highlights 10892 hits

We have developed a new technique to better understand what happens to the microstructure inside a tablet during rapid disintegration.

Improved Process Understanding of Tablet Film Coating

08 October 2014 in Research Highlights 16388 hits

Background Terahertz pulsed imaging (TPI) was first introduced in 2007 to non-destructively measure the coating thickness of pharmaceutical tablets. Ever…

Effect of Compression on Local and Segmental Mobility of PVPVA: Broadband Dielectric Spectroscopy Study

11 September 2014 in Research Highlights 15729 hits

Background The mechanism of plastic deformation in amorphous polymers is still obscure due to lack of experimental techniques to probe…

Nanocrystals - from fast dissolution and improved solubility to controlled release applications

02 July 2014 in Research Highlights 15232 hits

Problems related to low oral bioavailability due to poor solubility of new drug candidates are an increasing challenge in pharmaceutical…

Injection Molding as an Hot Melt Extrusion Downstream Process

28 May 2014 in Research Highlights 17736 hits

Introduction Over the last years, hot melt extrusion (HME) has attracted significant interest in the pharmaceutical industry. HME is performed…

Taste-Masking for Paediatric Medicines

15 November 2013 in Research Highlights 22644 hits

Introduction Following the implantation of European regulation with respect to medicinal products for paediatric use, scientist community has to speed…